The Role of BRG1 in Antioxidant and Redox Signaling

Table 2

The chemical modulators of BRG1. This list summarizes the current research on the chemical modulators of BRG1. BRG1: Brahma-related gene-1; BRM: Brahma; CDK: cyclin-dependent kinase; ENT: entinostat; HO-1: heme oxygenase 1; H/R: hypoxia/reoxygenation; IsoPostC: isoflurane postconditioning; NAC: N-acetylcysteine; Nrf2: nuclear factor E2-related factor 2; PPC: propofol postconditioning; SPostC: sevoflurane postconditioning; STAT3: signal transducer and activator of transcription 3; SWI/SNF: switch/sucrose nonfermentable.

Modulators	Known actions	Ref.
Chemicals
17β-estradiol	17β-estradiol antagonizes both the expression and activity of BRG1/BRM.	[58]
Adiponectin	Adiponectin promotes HO-1 induction by simultaneously activating Nrf2 and BRG1 to reduce cardiac oxidative stress, improve cardiac hypertrophy, and prevent left ventricular dysfunction in diabetic patients.	[39]
β-Adrenergic agonist	In vitro stimulation of myocardial cells with angiotensin II or a β-adrenergic agonist results in increased BRG1 expression.	[116]
CDK inhibitors	CDK9 inhibition dephosphorylates the SWI/SNF protein BRG1, which contributes to gene reactivation.	[127]
Darinaparsin	Darinaparsin inhibits HO-1 transcription by causing BRG1 phosphorylation through G2/M cell cycle arrest.	[33]
ENT	At the protein level, ENT reduces BRG1 protein abundance in Rh30 and U23674 cells, notably to an undetected level.	[128]
IsoPostC	Emulsified IsoPostC protects the heart through BRG1/Nrf2/STAT3 signaling.	[38]
NAC	The enhanced expression of BRG1 may be a new mechanism by which antioxidant NAC provides cardiac protection.	[36]
Oridonin	Oridonin inhibits proliferation of Jurkat cells via the downregulation of BRG1.	[129]
PFI-3	PFI-3 is a highly potent, selective, and cell-permeable inhibitor for the BRG1/BRM.	[130, 131]
Phosphoaminoglycosides	Preparations of phosphoaminoglycosides were identified as inhibitors of the in vitro activities of three SWI2/SNF2 family members.	[132]
PPC	PPC provides protection to H/R-induced L02 cells by activating Nrf2 and BRG1.	[41]
Propofol	Propofol alleviates oxidative stress in anoxia/reoxygenated hepatocytes by upregulating lncrna-TUG1/BRG1 pathway.	[40]
Rosiglitazone	The expression of BRG1 was significantly increased in cardiac remodeling heart, and the change can be reversed by rosiglitazone.	[124]
SPostC	SPostC prevents hypoxia-reoxygenation-induced cardiomyocyte damage and oxidative stress by activating Nrf2/BRG1/HO-1 signaling.	[37]
Tetrandrine	Tetrandrine upregulated BRG1 expression in a dose- and time-dependent pattern in Hep-2 cells.	[133]