AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress
Effects of AdipoRon on renal functional and morphological changes in db/db mice: (a) body weight changes in three mouse groups from 16 weeks to 20 weeks; (b) blood glucose levels; (c) serum creatinine concentrations; (d) proteinuria/24 h in each group; (e) urinary 8-OHdG levels; (f) serum adiponectin levels; (g) HE (upper panels), PAS (middle panels), and Masson staining (bottom panels) of renal tissue sections from db/m, db/db, db/db mice treated with AdipoRon, and 16-week-old db/db mice before the treatment. mice per group. . (h, i) Quantitative analysis of the tubular interstitial damage score and mesangial expansion score in each group. The data are expressed as the . versus db/m control mice; # versus db/db mice. HE: hematoxylin and eosin; PAS: periodic acid-Schiff.
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