Research Article

Dexmedetomidine Ameliorates Lung Injury Induced by Intestinal Ischemia/Reperfusion by Upregulating Cannabinoid Receptor 2, Followed by the Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway

Figure 8

The effects of dexmedetomidine treatment on the protein expressions of cleaved caspase-3, Bax, Bcl-2, and p-Akt in all groups. (a) The expressions of cleaved caspase-3, Bax, Bcl-2, and p-Akt in lung tissues were detected using Western blot analysis. (b) Cleaved caspase-3 expression. (c) Bax expression. (d) Bcl-2 expression. (e) Bcl-2/Bax ratio. (f) p-Akt expression. Data are expressed as , rats per group. versus the Sham group, # versus the I/R group, & versus the DEX group. I/R: intestinal ischemia/reperfusion; DEX: dexmedetomidine-treated I/R; DA: dexmedetomidine- and AM630-treated I/R; AI: AM630-treated I/R; DW: dexmedetomidine- and wortmannin-treated I/R; WI: wortmannin-treated I/R.
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