Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration

Table 1

Occurrence and development of oxidative stress and neuroinflammation associated with PD.

	Oxidative stress	Neuroinflammation
Occurrence	(+) ROS	Microglia activation
Development	Broken redox balance	(+) Inflammation cytokine
Aggravation	(+) Lipid, neuromelanin, metal ions; (-) Glutathione	NLRP3 activation, lymphocyte infiltration, intestinal flora disorder
PD-associated genes	Parkin, PINK1, DJ-1, LRRK2
Consequence	DA damage