Berberine Attenuates Hyperglycemia by Inhibiting the Hepatic Glucagon Pathway in Diabetic Mice

Figure 3

BBR represses glucogenesis in glucagon-induced primary mouse hepatocytes and livers of ob/ob mice. (a) Glucose production from C57BL/6J primary hepatocytes incubated in the absence or presence of 10 μM BBR and/or 50 nM glucagon. , compared with the control group (). (b) Gene expression measured by quantitative PCR in primary mouse hepatocytes. , compared with the control group (). (c) Glucagon tolerance test. , compared with the control group (). (d) CREB protein expression levels in liver homogenates and hepatocytes of ob/ob mice treated with vehicle, glucagon, or BBR, as indicated. The data are expressed as the ().

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