Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote Kras/Lkb1/Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion

Figure 1

SUMOylation of NRF2 is critical for its inhibition of KLK LUAD cell migration and invasion. (a) Establishment of KLK LUAD A549 and H2122 cells, which have endogenous NRF2 knockdown, stably expressing NRF2 wild-type, and NRF2 K110R. (b) The migration of four stable cell lines derived from A549 and H2122 cells, as detected by Transwell assays (3 replicates per group). (c) The invasion of four stable cell lines derived from A549 and H2122 cell as detected by Transwell assay (3 replicates per group). KLK: Kras-activated mutation, Lkb1-inactivated mutation, and Keap1-inactivated mutation; LUAD: lung adenocarcinoma. , , and .

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