FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway

Figure 1

FNDC5 deficiency deteriorates Ang II-induced hypertension and vascular remodeling in mice. Ang II was infused subcutaneously with a micro-osmotic pump at 400 ng/Kg/min for 2 weeks in wild-type mice (WT) and FNDC5 knockout mice (KO). (a) Systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) in caudal artery were measured in awake state. (b) Representative images of Masson’s staining of aorta. (c) Bar graph showing the Masson’s staining analysis for media thickness and area in aorta. (d) FNDC5 mRNA and protein expressions. Values are . vs WT; ^† vs Ctrl; ^‡ vs 0 wks. per group.

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