FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway

<div>FNDC5 attenuates Ang II-induced oxidative stress in A7R5 cells. The cells were treated with FNDC5 (200 nM) for 2 h followed by Ang II (100 nM) for 24 h. (a) Representative images showing the ROS detected by dihydroethidium (DHE) staining. (b) Bar graph showing the relative fluorescence intensity of DHE. (c) NOX2 and NOX4 protein expressions. (d) FNDC5 mRNA and protein expressions. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway 

Figure 3 | FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway 