FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway

Figure 4

FNDC5 attenuates Ang II-induced NLRP3 inflammasome activation in A7R5 cells. The cells were treated with FNDC5 (200 nM) for 2 h followed by Ang II (100 nM) for 24 h. (a) NLRP3, ASC, procaspase-1, caspase-1, pro-IL-1β, and IL-1β protein expressions. (b) Representative images showing the immunofluorescence for NLRP3. Values are . vs Ctrl; vs PBS. per group.

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