Ceftriaxone Calcium Crystals Induce Acute Kidney Injury by NLRP3-Mediated Inflammation and Oxidative Stress Injury
Ceftriaxone calcium crystals upregulated the NLRP3 inflammasome axis. (a, b) Representative western blots and quantitative analysis for NLRP3 (a) and IL-1β (b) expression in the kidney tissues. β-Actin was used as the internal control. (c, d) Immunohistochemistry staining of NLRP3 in kidney tissue ((c) NC group, (d) group 1, μm). (e, f) Immunohistochemistry staining of IL-1β in kidney tissue ((e) NC group, (f) group 1, μm). (g, h) Semiquantitative analysis for NLRP3 (g) and IL-1β (h) using Image-Pro plus 6.0 software (the results are expressed as ; compared with the control group).
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