Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of <i>Akkermansia muciniphila</i>

<div>Andrographolide attenuated diabetes-associated redox disturbance and inflammation. (a) The relative gene expression from caecal tissue corresponding to redox status (A) <i>Nrf2</i>, (B) <i>Cat</i>, and (C) <i>Sod1</i> was determined. (b) The relative gene expression of inflammatory factors from caecal tissue including (D) <i>TNF-α</i> and (E) <i>IL-6</i> were determined. (c) The relative gene expression of the antimicrobial peptides from caecal tissue including (F) <i>Lyz1</i>, (G) <i>DefA</i>, and (H) <i>Pla2g2</i> was determined. Control: db/db mice administered with vehicle; AG: db/db mice administered with 150 mg/kg andrographolide. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of <i>Akkermansia muciniphila</i> 

Figure 5 | Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of Akkermansia muciniphila 