Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of Akkermansia muciniphila

Figure 9

Brief summary of the mechanism of andrographolide on diabetes. This study demonstrated that andrographolide ameliorated glucose intolerance and insulin resistance in db/db diabetic mice. Andrographolide exerted glucose-lowering effect through strengthening intestinal barrier function and increasing microbial composition of A. muciniphila, which illuminates a plausible approach to ameliorate T2D.