Oxidative Stress in Ischemic Heart Disease

Figure 5

Biogenesis of miR-155. ARE: antioxidant responsive element; Bach 1: BTB domain and CNC homolog 1; DICER: ribonuclease DICER; DROSHA: ribonuclease DROSHA; HO-1: heme oxygenase-1; KEAP1: Kelch-like ECH-associated protein 1; MAF: musculoaponeurotic fibrosarcoma; miR: microRNA; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NRF2: nuclear factor erythroid 2-related factor 2; RISC: RNA-induced silencing complex; ROS: reactive oxygen species; TNF-α: tumor necrosis factor-α; TNFR: tumor necrosis factor receptor.