Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms

Table 2

Quality assessment of included studies.

Study (years)	1	2	3	4	5	6	7	8	9	10	Total
Yang et al. [17]	√	√	√			√			√		5
Wei et al., 2013	√	√	√								3
Sundaramahalingam et al. [18]	√	√							√		3
Shin et al. [19]	√	√	√						√		4
Ma et al. [11]	√		√			√			√	√	5
Liu et al. [20]	√	√	√			√			√	√	6
Limón et al. [21]	√	√	√			√			√		5
Li et al. [22]	√	√	√			√			√		5
Zhang et al. [5]	√		√						√		3
Lee et al. [10]	√	√				√			√		4
Lee et al. [23]	√	√	√		√	√					5
Kumar et al., 2012	√	√							√		3
Kim et al. [25]	√	√				√					3
Geng et al. [26]	√	√	√			√					4
Chen et al. [27]	√		√						√		3
Ma et al. [28]	√		√			√			√	√	5
Tian et al. [29]	√					√					2
Zhou et al. [30]	√	√	√								3
Wang GM et al., 2017	√		√								2
Hu et al. [32]	√		√								2
Chen et al. [33]	√		√								2
Gu et al. [34]	√		√								2
Wu et al., 2004	√		√								2
Wen et al., 2009	√		√								2
Yang et al. [37]	√	√	√		√				√	√	6
Zhou et al. [38]	√		√								2
Jiang et al., 2007	√		√								2
Huang et al. [40]	√										1
Wang BL et al., 2017	√	√	√			√			√		5
Guo et al. [42]	√		√								2
Jiang et al. [43]	√		√						√		3
Yang et al. [44]	√		√								2
Wang et al. [45]	√	√	√								3
Ma et al. [46]	√		√			√			√		4

1: peer-reviewed publication; 2: statements describing control of temperature; 3: randomization to treatment group; 4: allocation concealment; 5: blinded assessment of outcome; 6: avoidance of anesthetics with known notable intrinsic neuroprotective properties; 7: use of animals with relevant comorbidities; 8: sample size calculation; 9: compliance with animal welfare regulations; 10: declared any potential conflict of interest.