The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Table 2

SIRT1 regulate neuroinflammation involved in the NF-κB pathway.

Chemical agents	Models	Involved mechanisms	Effect	Reference
Resveratrol	Rat astrocytes induced by amyloid-beta (Aβ)	Upregulation of SIRT1 decreases the nuclear translocation of NF-κB p65	Suppression of inflammatory cytokines (TNF-α, IL-1β, and MCP-1)	Zhao et al. [101]
Resveratrol	N9 microglia cell lines induced by amyloid-beta (Aβ)	Upregulation of SITRT1 decreases the nuclear translocation of NF-κB p65	Suppression of inflammatory cytokines (IL-1β, IL-6, and NO)	Zhao et al. [101]
Resveratrol	Primary glial from rat cortices induced by amyloid-beta (Aβ)	Upregulation of SIRT1 inhibits NF-κB p65 by deacetylating Lys310 residue	Suppression of iNOS and EGFP expression; improvement of the survival of MAP2-positive neurons	Chen et al. [102]
Resveratrol	Cerebral ischemia mouse model; primary cortical neurons induced by oxygen-glucose deprivation (OGD)	The high levels of acetylation of NF-κB p65 occur in mouse and cell models; resveratrol deacetylated the Lys310 in primary neurons after OGD	Suppression of LDH expression and improvement of the survival of neuronal cell	Lanzillotta et al. [103]
Resveratrol	Postoperative cognitive dysfunction (POCD) rat model	Upregulation of SIRT1 decreases the expression of acetyl-NF-κB p65 in the hippocampus	Suppression of inflammatory cytokines (TNF-α, IL-1β, and IL-6)	Yan et al. [73]
Resveratrol	LPS-induced depressive-like behaviors mouse model	Upregulation of SIRT1 decreases the expression of NF-κB in the hippocampus	Suppression of LPS-induced depression-like behaviors and the overactivation of microglia	Liu et al. [104]
Resveratrol	Alzheimer’s disease rat model induced by ovariectomized (OVX)+D-galactose (D-gal)	Upregulation of SITRT1 decreases the expression of NF-κB p65 in the hippocampus	Suppression of insoluble amyloid-beta (Aβ) and MMP-9; increase of the tight junction protein claudin-5	Zhao et al. [105]