The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Table 6

Synthetic drugs and natural compounds regulate traumatic brain injury by involving in SIRT1 in animal models.

Chemical agents	Models	Involved pathway	Effect	Reference
Resveratrol	TBI rats	SIRT1/NLRP3 inflammasome	Anti-inflammatory effects	Zou et al. [122]
Resveratrol	TBI mice	SIRT1/MAPK	Suppression of the astrocyte activation	Li et al. [126]
Resveratrol	TBI mice	SIRT1/autophagy	Neuroprotective effect	Zhang et al. [143]
Sirtinol	TBI rats	SIRT1/p38	Exacerbations of neuronal damage	Yang et al. [130]
Salermide	TBI mice	SIRT1/ERK1/2	Promotion of apoptotic neuron	Zhao et al. [131]
Berberine	TBI mice	SIRT1/p38	Neuroprotective effect	Wang and Zhang [144]
Polydatin	TBI rats	SIRT1/p38/p-PERK/XBP-1/ATF6	Antiapoptotic effects	Li et al. [145]
ω-3 PUFA	TBI rats	SIRT1/beclin-1	Antiapoptotic effects	Chen et al. [146]
ω-3 PUFA	TBI rats	SIRT1/HMGB1/NF-κB	Anti-inflammatory effects	Chen et al. [147]