Review Article
The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases
Table 8
Synthetic drugs and natural compounds regulate Parkinson’s disease by involving in SIRT1 in cell and animal models.
| Chemical agents | Models | Involved pathway | Effect | Reference |
| Resveratrol | 6-OHDA-treated SH-SY5Y cells | SIRT1/BMAL1 | Antioxidant effects | Wang et al. [179] | Resveratrol | Rotenone-induced SH-SY5Y cells | SIRT1/p53 | Suppression of neural apoptosis | Feng et al. [180] | Resveratrol | Rotenone-induced SH-SY5Y cells | AMPK/SIRT1/autophagy | Suppression of neural apoptosis and promotion of the degradation of α-synuclein | Wu et al. [181] | Oxyresveratrol | 6-OHDA-treated SH-SY5Y cells | SIRT1/JNK | Neuroprotective effects | Chao et al. [217] | DCHC | 6-OHDA-treated PC-12 cells | SIRT1 | Suppression of neural apoptosis | Tsai et al. [218] | SIRT1 viral plasmid | Rotenone-treated SH-SY5Y cells | SIRT1/NF-κB | Increase of cell survival and decrease of α-synuclein aggregates | Singh et al. [182] | EGCG | MPP+-treated PC12 cells | SIRT1/PGC-1α | Suppression of oxidative stress | Ye et al. [183] | ECH | MPP+-treated PC12 cells | SIRT1/FOXO1/autophagy | Increase of cell survival | Chen et al. [184] | Salidroside | MPP+-treated SH-SY5Y cells | SIRT1/MAPK | Suppression of neural apoptosis and oxidative stress | Wang et al. [185] | Resveratrol | MPTP-induced mouse model | SIRT1/PGC-1α | Neuroprotective effects | Mudò et al. [219] | Resveratrol | MPTP-induced mouse model | SIRT1/LC3 | Protect the loss of dopaminergic neurons and promote the degradation of α-synuclein | Guo et al. [186] | — | MPTP-induced mouse model | SIRT1 | SIRT1 knockout mice worsen movement function | Zhang et al. [187] | — | MPTP-induced mouse model | SIRT1 | SIRT1-transgenic mice fail to alleviate loss of nigrostriatal dopamine neurons | Kitao et al. [188] |
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MPP+: 1-methyl-4-phenyl-pyridine; DCHC: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one; EGCG: epigallocatechin-3-gallate; 6-OHDA: 6-hydroxydopamine; ECH: echinacoside; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
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