The Beneficial Roles of SIRT1 in Neuroinflammation-Related Diseases

Table 8

Synthetic drugs and natural compounds regulate Parkinson’s disease by involving in SIRT1 in cell and animal models.

Chemical agents	Models	Involved pathway	Effect	Reference
Resveratrol	6-OHDA-treated SH-SY5Y cells	SIRT1/BMAL1	Antioxidant effects	Wang et al. [179]
Resveratrol	Rotenone-induced SH-SY5Y cells	SIRT1/p53	Suppression of neural apoptosis	Feng et al. [180]
Resveratrol	Rotenone-induced SH-SY5Y cells	AMPK/SIRT1/autophagy	Suppression of neural apoptosis and promotion of the degradation of α-synuclein	Wu et al. [181]
Oxyresveratrol	6-OHDA-treated SH-SY5Y cells	SIRT1/JNK	Neuroprotective effects	Chao et al. [217]
DCHC	6-OHDA-treated PC-12 cells	SIRT1	Suppression of neural apoptosis	Tsai et al. [218]
SIRT1 viral plasmid	Rotenone-treated SH-SY5Y cells	SIRT1/NF-κB	Increase of cell survival and decrease of α-synuclein aggregates	Singh et al. [182]
EGCG	MPP+-treated PC12 cells	SIRT1/PGC-1α	Suppression of oxidative stress	Ye et al. [183]
ECH	MPP+-treated PC12 cells	SIRT1/FOXO1/autophagy	Increase of cell survival	Chen et al. [184]
Salidroside	MPP+-treated SH-SY5Y cells	SIRT1/MAPK	Suppression of neural apoptosis and oxidative stress	Wang et al. [185]
Resveratrol	MPTP-induced mouse model	SIRT1/PGC-1α	Neuroprotective effects	Mudò et al. [219]
Resveratrol	MPTP-induced mouse model	SIRT1/LC3	Protect the loss of dopaminergic neurons and promote the degradation of α-synuclein	Guo et al. [186]
—	MPTP-induced mouse model	SIRT1	SIRT1 knockout mice worsen movement function	Zhang et al. [187]
—	MPTP-induced mouse model	SIRT1	SIRT1-transgenic mice fail to alleviate loss of nigrostriatal dopamine neurons	Kitao et al. [188]

MPP+: 1-methyl-4-phenyl-pyridine; DCHC: 3-(2,4-dichlorophenyl)-7-hydroxy-4H-chromen-4-one; EGCG: epigallocatechin-3-gallate; 6-OHDA: 6-hydroxydopamine; ECH: echinacoside; MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.