Rh-CSF1 Attenuates Oxidative Stress and Neuronal Apoptosis via the CSF1R/PLCG2/PKA/UCP2 Signaling Pathway in a Rat Model of Neonatal HIE

Figure 9

Effects of rh-CSF1 on neuronal degeneration and apoptosis after HI at 48 h after HI. (a) Representative microphotographs of FJC staining in the ipsilateral cortex of the rat brain. (b) Representative microphotographs of TUNEL staining in the ipsilateral cortex of the rat brain. (c) Quantitative analysis of FJC-positive cells in the ipsilateral cortex. (d) Quantitative analysis of TUNEL-positive neurons in the ipsilateral cortex. vs. sham; ^# vs. HI+vehicle; ^@ vs. HI+rh-CSF1+DMSO; (FJC staining); (TUNEL staining), . The upper right panel of brain slice indicates the location for staining analysis (small blue box).