Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin

Figure 5

Functional implications of PTM and mutations of cytochrome c. Left: chemical modifications of cytochrome c residues. Right: ribbon representation of oxidized human Cc (PDB 2N9J) [92]. Residues are colored by type of PTM: pink for nitration, purple for sulfoxidation, orange for phosphorylation, brown for carbonylation, cyan for N-homocysteinylation, and blue for point mutations. Y48 (asterisk) can be either phosphorylated, nitrated, or mutated for histidine, while Y97 (asterisk) can be phosphorylated or nitrated.