Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin

Table 1

Effect of PTM and point mutations on cytochrome c peroxidase activity.

Cc PTMs/mutation		Effect on peroxidase activity	References
Sulfoxidation^a
M80		↑	[168, 187, 196]
Nitration^b
Y46		↑	[184]
Y48		↑	[184]
Y67		↑	[185, 197]
Y74		↑	[185, 197]
Y97		↑	[185, 197]
Carbonylation^c
K53		↑	[152]
K55		↑	[152]
K72		↑	[152]
K73		↑	[152]
Phosphorylation
T28	T28D	↑	[192]
T28	T28E	↓	[195]
S47	S47D	≈	[192]
Y48	Y48E	↑/↓	[176, 190]
	Y48pCMF	↑	[194]
Y97	Y97E	≈	[176]
	Y97pCMF	≈	[193]
N-Homocysteinylation^d
K8/K13		↑	[198]
K86/87		↑	[198]
K99		↑	[198]
K100		↑	[198]
Point mutation
G41S		↑	[181, 199]
Y48H		↑	[181, 200]

^aDetermined under oxidative stress. ^bDetermined after peroxynitrite treatment. ^cDetermined after chloramine-T treatment. ^dDetermined after homocysteine thiolactone treatment.