Effects of Plant and Animal Natural Products on Mitophagy

Table 1

Studies reporting the effects of natural compounds on mitophagy.

Natural product	Dose	Experimental model	Effect	Ref.
Resveratrol	100 mg/kg	Diquat-challenged piglets	Induced mitophagy	[8]
	0, 5, 50, and 500 mg/kg	mdx mice	Induced mitophagy	[33]
	0.04, 0.4, and 4 g/kg	mdx mice	Induced mitophagy	[34]
	1, 10, and 50 μM	GRX cells	Induced mitophagy	[14]
	0.001-1000 μM	MDA-MB-231, MCF-7, SiHa, HeLa, Saos-2, HUVEC cells	Induced mitophagy	[35]
	Diet containing 0.04% resveratrol	Streptozocin-induced diabetes in mice	Inhibited mitophagy	[70]
	3 μM	Aβ1–42-treated PC12 cells	Induced mitophagy	[71]
	0, 25, and 50 μmol/l	PD solution-induced peritoneal inflammatory injury in HPMCs	Induced mitophagy	[15]
Curcumin	10 μM	Nasopharyngeal carcinoma CNE2 cells	Induced mitophagy	[48]
	200 mg/kg	Cisplatin-induced renal damage in rats	Inhibited mitophagy	[72]
	25 μM	Human hepatoma-derived Huh-7 cells	Induced mitophagy	[49]
	25 μM	U-87MG, GL261, F98, C6-glioma, and N2a cells	Induced autophagy; Inhibited mitophagy	[50]
SLCP
E. uniflora	5, 50, and 100 μg/ml	GRX cells	Induced autophagy	[22]
G. formosana	0, 15, 30, 45, 60, 75, 90, 105 μg/ml	HeLa, HepG2, and MCF7 cells	Induced autophagy	[54]
Berberine	100 nM	H9C2 cell line	Induced mitophagy	[73]
P. americana	0.25, 0.5, 1.0, 2.0, and 4.0 mg/ml	LPS-induced injury in H2C9 cells	Induced mitophagy	[88]
P. suffruticosa	25–2500 μg/ml	PANC1, AsPC1, and BxPC3 cells	Induced mitophagy	[60]
Quercetin	100 mg/kg	Ethanol-induced hepatic damage in mice	Induced mitophagy	[27]
	100 mg/kg	HFD-induced hepatic steatosis in mice	Induced mitophagy	[28]
	100 μM	HepG2 cell
Quercetogetin	6.25, 12.5, 25, 50, and 100 μM	Cigarette smoke extract-induced lung epithelial cell injury	Inhibited mitophagy	[89]
SAV	500, 1000, and 2000 mg/kg; 0.5-4.5 mg/ml	BB-induced hepatotoxicity in mice; LO2 and HepG2 cells	Induced mitophagy	[32]
Sulforaphene	0-20 μM	U937, HUT78, Raji, JeKo-1, and U2932 cells	Induced mitophagy	[65]
Tomatidine	0, 25, and 50 μM	C. elegans	Induced mitophagy	[92]
Toxicarioside	0-0.8 μM	A549 and H460 cells	Induced mitophagy	[69]

Abbreviations: Aβ_1–42: amyloid beta-peptide_1-42; Atg7: autophagy-related protein 7; BB: bromobenzene; C. elegans: Caenorhabditis elegans; E. uniflora: Eugenia uniflora; FFA: free fatty acid; G. formosana: Gynura formosana; HFD: high-fat diet; HPMCs: human peritoneal mesothelial cells; HUVEC: human umbilical vein endothelial cell; LPS: lipopolysaccharide; P. americana: Periplaneta americana; PD: peritoneal dialysis; P. suffruticosa: Paeonia suffruticosa; SAV: Shanxi aged vinegar; SLCP: solid lipid curcumin particles.