Research Article
Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats
Figure 4
H2 improved learning and memory of HIBI rats during adulthood. (a) Diagrams indicating movement of rats in the normal (A), sham surgery (B), HIBI (C), H2-30 min (D), H2-60 min (E), H2-90 min (F), H2-90 min (12 h) (G), and H2-90 min (24 h) (H) groups to locate the escape platform during the day 4 training trial. (b) Diagrams indicating 60 s movement of rats in the normal (A), sham surgery (B), HIBI (C), H2-30 min (D), H2-60 min (E), H2-90 min (F), H2-90 min (12 h) (G), and H2-90 min (24 h) (H) groups to locate the escape platform during the day 5 probe trial. (c) Bar graph of latency to locate the escape platform during training trials on days 1 through 4 in different groups of rats (; ; ). (d) Spatial preference (percentage of time spent) in the escape platform quadrant during the day 5 probe trial (; ; ).