Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats

<div>Effects of H<sub>2</sub> gas on MAPK/Nrf2/HO-1 protein expression<i>.</i> (a) Representative images of p-p38 MAPK (green), Nrf2 (red), HO-1 (red), and DAPI (blue) immunofluorescence staining of the rat cortex in the sham surgery, HIBI, and H<sub>2</sub>-90 min groups (scar bar: 20 <i>μ</i>m). (b) p-ERK, p-P38 MAPK, p-JNK, Nrf2, and HO-1 protein expressions were analyzed by western blot analysis in each group of <i>β</i>-NGF-differentiated PC12 cells. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats 