A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction

Figure 2

Effects of IKKε deficiency on survival, infarct size, and cardiac function after MI. (a) Representative western blots of IKKε expression in heart tissues from wild-type (WT) littermates and KO mice ( for each group). (b) Kaplan-Meier survival analysis for WT MI and KO MI mice ( for WT MI group, for WT MI group). (c) Echocardiographic analysis of (d) left ventricular end diastolic diameter (LVEDd), (e) left ventricular end systolic diameter (LVESd), (f) fractional shortening (FS), and (g) ejection fraction (EF) at day 28 after the MI or sham operation ( for each group). NS: not significant; ; . (h) Representative images of micro-PET, micro-CT, and micro-PET/CT overlap form WT and KO mice at day 28 after MI or sham operation. (i) Quantitative analysis of infarct size at day 28 post-MI in WT and KO mice ( for each group). .

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