A Novel Molecular Mechanism of IKKε-Mediated Akt/mTOR Inhibition in the Cardiomyocyte Autophagy after Myocardial Infarction
Knockdown of IKKε promotes starvation-induced autophagy in H9c2 cells. (a, b) Representative western blots and quantitative results of IKKε, LC3I/II, ATG-5, C-caspase 3, Bcl-2, and Bax in H9c2 cells ( for each group). ;;. (c) Representative immunofluorescent staining of LC3 in H9c2 cells ( for each group; magnification, 600x). Scale bar represents 10 μm. (d) The quantification of autophagy is expressed as the number of LC3 puncta per area ( for each group). .
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.