Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway
Methane alleviated LPS-induced histological changes in the testes of rats with LPS-induced acute orchitis. Spermatogenic cells were arranged in a concentric distribution in the Control (a) and MS (b) groups. Deleterious effects appeared in the LPS (c) and MS-LPS (d) groups at 72 h following LPS administration, including loss of germ cells, disorganization, and disruption of spermatogenic cells (black arrows). .
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