Research Article
Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities
Figure 5
Therapeutic efficacy of CAPE in MOG35-55-induced EAE mice. Mice were immunized with MOG35-55 peptide emulsified in complete Freund’s adjuvant. Daily CAPE administration was initiated on the day of immunization (pretreatment) or on the day of symptom onset (treatment). Body weights and EAE scores were evaluated starting on the day of immunization. Different regimens of CAPE administration in EAE mice (a). The impacts of different regimens and doses on the course of EAE (b). Inflammatory infiltration assessed by HE staining (c), microglia/microphage activation assessed by Iba-1, and demyelination demonstrated by MBP (d) in EAE mice. HE scores, demyelination scores, cell infiltration, and the proportion of T cells in EAE mice (e). Each group contained 10 mice. Data are presented as the . , , , versus the vehicle group.
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