Roles of TRP Channels in Neurological Diseases

Table 2

Evidence of proposed functions of TRPs and possible relationships to neurological disorders in humans.

TRP channels		Evidence of expression	Proposed functions	Related disorders	References
TRPC subfamily	TRPC1	Human glioma cell lines	Impaired cytokinesis and facilitated glioma cell migration	Malignant gliomas	[85, 86]
	TRPC3	Human cerebral vascular tissue after hypertensive ICH	Decreased expression from hypertensive patients after intracerebral hemorrhage with unknown function	Hypertensive ICH	[79]
	TRPC1, 3, 5, 6	Human glioma cell lines	Impaired cytokinesis to become nuclear atypia and enlarged cells induced by TRPC inhibition	Malignant gliomas	[85]
TRPV subfamily	TRPV2	Human glioma cell lines	Increased chemotherapeutic drug uptake and cytotoxic activity	Glioblastoma multiforme	[87]
TRPML subfamily	TRPML2	Human glioma tissues of different levels and high-grade glioma cell lines of astrocytic origin	Increased survival and proliferation in glioma cell lines	Glioma	[88]