Roles of TRP Channels in Neurological Diseases

Table 3

General features and pharmacological interventions targeting TRP channels in neurological diseases.

TRP channels		Ion permeability	General physiological functions	Pharmacological interventions	References
TRPC subfamily	TRPC3	Nonselective cation	Neuronal differentiation, growth cone guidance, vasomotor	Pyr3 for stroke, epilepsy	[77, 100, 101]
	TRPC6	Nonselective cation	Axon guidance, vasomotor, smooth muscle, mechanosensor	Hyperforin for stroke, epilepsy; Resveratrol for stroke; OAG for AD	[55–58, 89, 101]
TRPV subfamily	TRPV1	Ca^2+ permeable	Sensing spicy (hot) peppers, pain sensation, noxious temperature sensing	Dihydrocapsaicin for stroke; Capsazepine for epilepsy, AD, PD, stroke; Capsaicin for PD, schizophrenia; Anandamide for epilepsy; AMG9810, oleoylethanolamide for PD	[70, 71, 97–99, 102, 103, 107]
	TRPV2	Weakly Ca^2+ selective	Thermal pain sensing, mechanosensor	Cannabidiol for glioblastoma, epilepsy	[87, 105]
	TRPV4	Ca^2+ permeable	Osmosensing, warm sensing, nociception, pressure sensing	HC-067047 for stroke, AD, epilepsy; GSK1016790A for stroke	[73, 78]
TRPM subfamily	TRPM2	Nonselective cation	Oxidant stress sensing	Tat-M2NX for stroke; SB-750139 for AD; 2-Aminoethoxydiphenyl borate for AD; N-(p-Amylcinnamoyl) anthranilic acid for AD, PD; Flufenamic acid for PD	[62, 90, 91, 95]
	TRPM4	Ca^2+ impermeable	Mechanosensor	9-Phenanthrol for stroke	[69]
	TRPM7	Mg^2+ permeable	Mg^2+ homeostasis, entry pathway for trace metals	Carvacrol for stroke	[68]
TRPA subfamily	TRPA1	Nonselective cation	Pungent painful stimuli sensing, noxious cold sensing, mechanosensor	HC-030031 for AD	[93]