Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway

Figure 1

OGD/R model establishment, and effects of PNGL and FK866 on normal SH-SY5Y cell viability. The ischemia cell model condition was the OGD treatment for 4 h and followed 24 h reperfusion in vitro. (a–d) The effects of OGD followed reperfusion on SH-SY5Y cells for various times, which induce the OGD/R cell model. (e) The toxic effect of PNGL treatment on SH-SY5Y cells. (f) The toxic effect of FK866 treatment on SH-SY5Y cells. The copretreatment of PNGL and FK866 for 24 h, followed by OGD/R treatment. The cell viability was measured by using the MTT assay. The data presented as the . ^#, ^## versus the control group; , versus the OGD/R model group; ^&, ^&& versus the OGD+PNGL group.

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