Research Article
Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the NAMPT-NAD Pathway
Figure 5
Effects of PNGL on the downstream SIRT1/2/3-Foxo3a-MnSOD/PGC-1α signaling pathway in the OGD/R-induced SH-SY5Y cells. PNGL regulated the MnSOD, PGC-1α, Foxo3a, and p-Foxo3a expression levels, which was partly reversed by the inhibitor FK866 in vitro. (a) The protein bands of the MnSOD, PGC-1α, Foxo3a, and p-Foxo3a were examined by western blot analysis in the OGD/R-induced SH-SY5Y cells. (b–e) The expression levels of the proteins were quantified and analyzed using the Gel-Pro analyzer software. The data presented as the . #, ## versus the control group; , versus the OGD/R model group; &, && versus the OGD/R+PNGL group.
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