Research Article
Chrysophanol Alleviates Metabolic Syndrome by Activating the SIRT6/AMPK Signaling Pathway in Brown Adipocytes
Figure 3
Chrysophanol regulated FAO and lipolysis in iWAT of HFD-induced obese mice. (a) The expression of adipose maker, lipolysis, FAO, thermogenesis, and oxidative phosphorylation (OXPHOS) relative mRNA in the iWAT of HFD-induced obese mice was measured by real-time quantitative PCR. (b, c) The p-HSL (Ser660), HSL, AMPK, and p-AMPK protein levels in the iWAT of HFD-induced obese mice were determined by Western blotting. All data are expressed as the . , compared with the control group. Mice treated with a 12.5 mg/kg dose of chrysophanol ().
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