Oleanolic Acid Decreases IL-1β-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-κB Axis in Osteoarthritis

Figure 4

Effect of SIRT3 on the IL-1β-induced NF-κB signal activation in human FLS. FLS were pretreated with SIRT3-OE or SIRT3-KD and then incubated with or without IL-1β (10 ng/ml) for 30 min. A Western blot analysis and quantitative analysis of p-NF-κB/NF-κB and acetyl-NF-κB/NF-κB in human FLS. The values are expressed as (SD), .