DHA Supplementation Attenuates MI-Induced LV Matrix Remodeling and Dysfunction in Mice

<div>Improved cardiac function in DHA-supplemented mice after MI: functional parameters of (a) left ventricular end-systolic pressure (LVESP), (b) left ventricular end-diastolic pressure (LVEDP), (c) ejection fraction (EF), (d) peak pressure decline (<span class="nowrap"><svg height="12.4894pt" id="M23" style="vertical-align:-3.181499pt" version="1.1" viewbox="-0.0498162 -9.3079 46.297 12.4894" width="46.297pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M517 51L485 54C448 58 441 63 441 115V712C404 700 337 684 285 678V653C357 648 362 645 362 580V437C339 446 309 449 295 449C159 449 38 340 38 201C38 61 143 -12 223 -12C234 -12 261 -6 301 17L362 53V-12C420 9 495 22 517 26V51ZM362 85C338 67 301 51 266 51C201 51 128 109 128 228C128 373 212 411 259 411C296 411 338 395 362 360V85Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.864,0)"><path d="M46 650V622C120 617 128 613 128 525V125C128 42 120 34 40 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319C131 350 139 371 152 384C163 397 178 404 197 404C246 404 281 365 281 293V278C260 262 186 232 124 213C69 194 41 161 41 112C41 47 92 -12 163 -12C195 -12 243 25 283 51C288 35 293 22 308 7C319 -4 339 -12 354 -12L442 39ZM281 87C262 68 226 51 199 51C169 51 129 74 129 126C129 162 151 181 190 198C211 208 259 229 281 240V87Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,42.115,3.132)"><path d="M482 0V30C420 38 407 48 370 103L273 248C308 299 331 332 352 357C387 397 401 404 463 409V439H277V409C318 405 324 400 307 369C290 337 270 307 251 279L194 367C175 396 180 402 220 409V439H18V409C74 401 87 395 117 349L204 213C173 168 147 130 119 95C78 46 67 38 5 30V0H195V30C144 38 143 47 162 79C181 112 202 149 225 181L297 70C314 43 307 35 264 30V0H482Z"></path></g></svg>),</span> and (f) isovolumic relaxation constant (Tau), were analyzed 14 d after sham or MI in CD- or DHA-supplemented mice. <svg height="8.55521pt" id="M25" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: DHA Supplementation Attenuates MI-Induced LV Matrix Remodeling and Dysfunction in Mice 