Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence

<div>Effects of paricalcitol on oxidative stress and apoptosis in the kidney after ioversol administration. Immunohistochemical staining was performed with a specific antibody against 8-OHdG. Densitometric quantification for 8-OHdG was applied to each group. Ioversol-induced apoptosis was detected using the TUNEL assay. TUNEL-positive cells were stained with dense brown spots and counted as described in Materials and Methods. Apoptotic signals were found by TUNEL staining. Images are representative of each group. Con: PBS-treated group; PC: paricalcitol-treated group; CONT: ioversol-treated group; PC+CONT: paricalcitol- and ioversol-treated group. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Paricalcitol Attenuates Contrast-Induced Acute Kidney Injury by Regulating Mitophagy and Senescence 