Cornelian Cherry Iridoid-Polyphenolic Extract Improves Mucosal Epithelial Barrier Integrity in Rat Experimental Colitis and Exerts Antimicrobial and Antiadhesive Activities In Vitro

Figure 7

The impact of cornelian cherry iridoid-polyphenolic extract and loganic acid on the gene expression of transcription factor STAT3 (a), intestinal mucosal barrier protein Muc2 (b), and TFF3 (c) in experimental groups. Control = control group; TNBS = group receiving only TNBS; CE20, CE100 = groups receiving 20 or 100 mg/kg cornelian cherry extract with TNBS, respectively; LA10, LA50 = groups receiving 10 or 50 mg/kg loganic acid with TNBS, respectively; SA = group receiving 100 mg/kg sulfasalazine with TNBS; CE20+SA, CE100+SA = groups receiving 20 or 100 mg/kg cornelian cherry extract and 100 mg/kg sulfasalazine with TNBS, respectively; and LA10+SA, LA50+SA = groups receiving 10 or 50 mg/kg loganic acid and 100 mg/kg sulfasalazine with TNBS, respectively. Relative expression levels were analyzed by qPCR. Data are presented as . Differences ^{^} vs. the control group; ^{^^} vs. the control group; vs. the TNBS group; vs. the TNBS group; vs. the TNBS group; and ^# vs. the sulfasalazine group were deemed statistically significant.

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