A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3

Figure 8

PL171 restored Aβ₄₂O-induced cell senescence through SIRT3 modulation. (a) The representative images presenting SA-β-gal staining in the cells preincubated with PL171 (30 μM) for 4 h followed by Aβ₄₂O (10 μM) challenge for 72 h. The images were obtained by a Zeiss Observer Z1 microscope. Scale bars, 50 μm. (b) The quantification of relative number of SA-β-gal positive cells in (a). (c) The representative images of SK-N-SH cells treated as indicated for 72 h and stained for SA-β-gal. Scale bars, 50 μm. (d) Quantification of relative number of SA-β-gal positive cells in (c). The data are presented as , independent experiments, and , analyzed by one-way ANOVA followed by Bonferroni’s test.

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