Water-Soluble Pristine C₆₀ Fullerenes Inhibit Liver Fibrotic Alteration and Prevent Liver Cirrhosis in Rats

Table 1

Fibrotic and other pathological alterations of the liver for rats that experienced DEN+CCl₄ fibrosis and cirrhosis and treated by C₆₀FAS.

Parameters	10 weeks			15 weeks
	Control	Fibrosis	Fibrosis+C60FAS	Control	Cirrhosis	Cirrhosis+C60FAS
Liver damage score	0			0
Ishak score	0			0
Lipid dystrophy of hepatocytes	-	+	+	-	++	++
Balloon dystrophy of hepatocytes	-	-	-	-	++	+
Ground-glass hepatocytes	-	+	-	-	++	-
Eosinophilic hepatocyte alteration	-	++	-	-	+	-
Hepatocellular hypertrophy	-	+	+	-	+	+
Necrotic hepatocytes	-	+	++	-	++	++
Blood vessel dilation	-	-	-	-	+	-
Inflammatory cell accumulation	+	+	+	+	++	++

Trait intensity: “-”: not observed; “+”: single or slight; “++”: moderate; “+++”: strong. compared to control; compared to the fibrosis/cirrhosis group.