Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity

Figure 7

Assessing the interaction properties of quercetin with the two subunits of P-gp efflux pump (P-gp ATPase and substrate binding site) using sodium vanadate (Sod. vanadate) and verapamil (VRP) as positive controls, respectively (a), and compared to the nontreated control (NTC). The intracellular concentrations of the fluorescent P-gp substrate (rhodamine) was measured after treating MCF-7 cells (b), MDA-MB-231 cells (c), and T47D cells (d) for 24 h with serial concentrations of quercetin or verapamil and compared to rhodamine alone. Data is presented as ; . Significantly different from NTC at . ^#Significantly different from the Rho group at .

(a)

(b)

(c)

(d)