Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity

Table 1

Effect of quercetin on the cytotoxicity parameters of DOX in breast cancer cell lines. IC₅₀s and resistance fraction ( values) were calculated using mathematical model as shown in Materials and Methods. IC₅₀ is the concentration of a drug or drug combination killing 50% of the cells, and value is the percentage of cell resistance to drug/drug combination at the highest possible concentration of exposure.

	MCF-7		MDA-MB231		T47D
	IC50 (μM)	value (%)	IC50 (μM)	value (%)	IC50 (μM)	value (%)
DOX
Quercetin
DOX+Que
CI value	Antagonistic/3.16		Antagonistic/2.04		Additive/0.96