Review Article

The Great Healing Potential Hidden in Plant Preparations of Antioxidant Properties: A Return to Nature?

Table 12

The protective effects of plant origin materials in the animal model of menopause.

ReferencePlant extract, dose, way and time of treatment, and animalsInducing factor and negative effectsProtective effects of plant materialEffects of plant per se

Leung et al. [115]Camellia sinensis O. Ktze (black tea) extract (QP-lack tea extract, Quality Phytochemicals LLC)
15 mg/kg/day, i.g., for 4 weeks, 3 months after ovariectomy
Female Sprague-Dawley rats, 3 months, 200–230 g
Ovariectomy
Body weight: ↑
Serum: 17β-estradiol, cGMP ↓, non-HDL-c, HDL-c, TC, TG ↑
Aorta: peNOS ↓, NOX2, NOX4 ↑
Endothelium of aorta: ROS ↑
Body weight: (0)
Serum: TG ↓, 17β-estradiol, non-HDL-c (0), HDL-c, TC (++), cGMP (+++)
Aorta: peNOS, NOX2, NOX4 (+++)
Endothelium of aorta: ROS (+++)
Not studied

Galanis et al. [114]Glycyrrhiza glabra root methanol extract, in the form of drinking water at such a volume so as to obtain the upper threshold of glycyrrhizin (the main active component) of 12.4 mg/kg/rat per day, a day after surgery, for 3 or 6 months
Female intact mature Wistar rats, 10 months
Ovariectomy
Total tibia bone mineral density: after 3 and 6 months ↓
Proximal tibia bone mineral density: after both 3 and 6 months ↓
Uterine weight: after 6 months ↓
Total tibia bone mineral density: (+++ after 3 months, ++ after 6 months)
Proximal tibia bone mineral density: after 3 months (+++), after 6 months (++)
Uterine weight: (++)
Not studied

Hamm et al. [116]Humulus lupulus L., hops flavonoid-rich extract (MetaGenics, Aliso Viejo, CA, USA)
400 mg/kg in food, daily, for 11 weeks
Female C57BL/6 mice, 7 months
Ovariectomy
Uterus weight ↓
Visceral adipose tissue weight ↑
Liver: TG ↑
Ileum: ALP ↑
Uterus weight (0)
Visceral adipose tissue weight (+)
Liver triglycerides (+++)
Ileum: ALP (0)
Uterus weight ↓
Ileum: ALP ↑

↓: a decrease vs. control; ↑: an increase vs. control; (+): a slight beneficial effect; (++): a distinct beneficial effect; (+++): a complete beneficial effect; (0): no beneficial effect.