| | Reference | Plant extract, dose, way and time of treatment, and animals | Inducing factor and negative effects | Protective effects of plant material | Effects of plant per se |
| | de Toledo Espindola et al. [121] | Campomanesia adamantium root aqueous extract
200 mg/kg b.w., p.o., 8 weeks after hyperlipidemia
Wistar rats, 60 days, 140-150 g | Hyperlipidemia induced by high fructose diet for 16 weeks
Body weight gain: ↑
Serum: TC, TG ↑ | Body weight gain: (++ during the experiment, + in the end)
Serum: TC, TG (+++) | Not studied |
| | Veber et al. [34] | Brassica oleracea L. red cabbage aqueous extract
125 or 250 mg/kg, p.o., twice a day, for 3 days
Male Wistar rats, 200-300 g | Hyperlipidemia induced by
a single administration of Triton WR-1339
400 mg/kg, i.p.
Serum: MDA, PC ↑
RBC: SOD ↑, CAT ↓
Liver: MDA, PC, SOD, GPx ↑, CAT ↓
Kidney: MDA, PC, GPx ↑, SOD, CAT ↓
Cerebral cortex: SOD ↓, MDA, PC ↑
Hippocampus: SOD, CAT ↓, GPx, MDA ↑ | Serum: MDA (0 both doses), PC (0 125, +++ 250)
RBC: CAT (0 125, +++ 250), SOD (+++ both doses)
Liver: CAT (0 125, +++ 250), PC (+++ 125, ++ 250), MDA, SOD, GPx (+++ both doses)
Kidney: MDA(0 both doses), GPx (0 125, +++ 250), PC, SOD, CAT (+++ both doses)
Cerebral cortex: SOD (0 125, +++ 250), PC (++ 125, +++ 250), MDA (+++ both doses)
Hippocampus: SOD (0 125, +++ 250),MDA (++ 125, +++ 250), CAT and GPx (+++ both doses) | Not studied |
| | Khlifi et al. [120] | Erica multiflora L. leaf methanolic extract
Pretreatment 150 or 250 mg/kg, i.g., 1 hour before Triton WR-1339
Male Wistar rats, 150-200 g | Triton WR-1339-induced hyperlipidemia, a single dose 300 mg/kg, i.p.
Serum: HDL-c ↓, TC, TG, VLDL-c, LDL-c↑
Plasma: ALT, AST ↑
Liver: SOD, GPx, CAT ↓, MDA ↑
Liver: total DNA damage ↑ | Serum: HDL-c (0 150, ++ 250), TG, VLDL-c, LDL-c (++ both doses), TC (++ 150, +++ 250)
Plasma: ALT (++ 150, +++ 250), AST (+++ both doses)
Liver: SOD (+ 150, ++ 250), MDA (++ both doses), GPx (+ 150, +++ 250), CAT (++ 150, ++ 250)
Liver: total DNA damage (++ both doses) | 250 mg/kg only studied:
Serum: VLDL-c, TG ↑
Liver: SOD ↑ |
| | Onyenibe et al. [122] | Monodora myristica fruit aqueous extract
100 or 200 mg/kg b.w., p.o., five times a week for 8 weeks
Male Wistar albino rats, 120-140 g | Hypercholesterolemia induced by cholesterol, p.o.
40 mg/kg/0.3 mL, five times a week for 8 weeks
Serum: HDL-c ↓, LDL-c, TC, TG, AST, ALT ↑
Liver: SOD, CAT, GSH ↓, MDA ↑
Heart: SOD, CAT ↓, MDA ↑ | Serum: LDL-c (0 100, + 200), AST, TC (++ both doses), TG, ALT (+++ both doses), HDL-c (↑ both doses)
Liver: MDA (++ both doses), SOD, CAT, GSH (+++) both doses
Heart: MDA (++ 100, +++ 200), SOD (+++) both doses, CAT (↑ both doses) | Not studied |
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