| | Reference | Plant preparation, dose, way and time of treatment, and animals | The dose, way and time of exposure, and negative effects | Protective effects of plant preparation | Effects of plant per se |
| | Akbari et al. [93] | Zingiber officinale Roscoe (ginger) rhizome hydroalcoholic extract
1 g/kg of b.w./d, p.o., for 28 days
Sprague-Dawley male rats, about 220 g | Ethanol 4 g/kg of b.w./d, p.o., for 28 days
Serum: T, SHBG, DHEAs ↓
Testes: weight, Zn, Mg, Fe, Cu ↓; SOD, GPx, CAT ↓, MDA, tHcy ↑ | Serum: T (++), SHBG, DHEAs (+++)
Testes: Zn (-), Cu (+), Mg, weight, SOD, GPx, CAT, MDA, tHcy (+++),
Fe (↑) | Serum: T ↓
Testes: Fe ↑, Zn, Mg, Cu ↓ |
| | Phunchago et al. [92] | Tiliacora triandra aerial parts aqueous extract, 100, 200 or 400 mg/kg b.w., p.o., for 14 days after developing ethanol dependence by15-week alcohol treatment
Male Wistar rats, 8 weeks | Ethanol-dependence caused by a gradual increase of ethanol content in drinking fluid from 5% up to 30%, a 15-week alcohol treatment
Hippocampus: AChE, MDA ↑, SOD, CAT, GPx ↓, neuron density in subregions CA1, CA2, CA3 and dentate gyrus ↓ | Hippocampus: AChE (+ 100, ++ 200, 0 400), CAT (+++ 100 and 200, ++ 400), GPx (↑ 100 and 200, +++ 400), MDA, SOD (++ all doses), neuron density in subregions CA1, CA2, and CA3 and dentate gyrus (++ all doses) | Not studied |
| | Liu et al. [91] | Ginseng oligopeptides extracted from roots of Panax ginseng C.A. Meyer (Jilin Taigu Biological Engineering Co., Ltd., China)
Pretreatment: 0.0625, 0.125, 0.25, and 0.5 g/kg b.w., for 30 days, p.o.,
Sprague-Dawley male rats, 180-220 g | One dose of 50% ethanol
7 g (17.5 mL)/kg b.w., i.g.
Serum: ALT, AST, TG, ALP, TNF-α, IL-6, IL-1β and LPS ↑, TC, HDL-c, LDL-c, TP ↓
Liver: steatosis and MDA ↑, SOD, GSH, GPx ↓ | Serum: ALP (- lower doses, 0 the highest one); LDL-c, TP (0 all doses), HDL-c (0 the lowest dose, + other ones), TC (++ all doses), TG (++ lower doses, +++ higher ones), LPS (+++ except for 0.25 mg/kg ++), ALT, AST, (+++ all doses), TNF-α, IL-6 and IL-1β (↓ all doses)
Liver: steatosis (++ all doses), GPx (+ lower doses, +++ 0.25, ↑ 0.5), GSH (+ lower doses, +++ higher ones), MDA (+++ all doses), SOD (+ lower doses, ++ highest one) | Not studied |
| | Jung et al. [94] | Glycyrrhiza uralensis Fisher root
70% ethanol extract
100 mg/kg b.w., p.o., for 4 weeks
Male C57BL/6 mice | Dietary ethanol
Lieber–DeCarli liquid diet—36% of energy from ethanol, for 4 weeks
Serum: TNF-α, ALT, AST ↑
Liver: GSH ↓, TG and mRNA expression of Srebf1, Cd36, Lpl, Fatp4 ↑ | Serum: TNF-α, ALT, AST (++)
Liver: TG, mRNA expression of Srebf1, Cd36 and LpI (++), GSH and mRNA expression of Fatp4 (+++) | Not studied |
| | Lou et al. [65] | Linderae radix (prepared slices, Zhejiang Tiantaishan Wuyao Biological Engineering Co., Ltd., China) extracted from tubers of Lindera aggregata (Sims) Kostern, 75% ethanol extract
1, 2 or 4 g/kg, i.g., for 20 days
Male Sprague-Dawley rats, 160–180 g | 50% alcohol
10 mL/kg b.w., once a day for 20 days, i.g.
Serum: ALT, total bilirubin, IL-6, IL-8, TNF-α, NF-κB ↑
Portal vein: LPS ↑
Small intestine: expression of tight junction proteins claudin-1 and occludin ↓ | Serum: IL-6 (+ 1 and 2, +++ 4), TNF-α (+++ 1, ++ 2, 0 4), NF-κB (++ 1, +++ 2, and 4), ALT, total bilirubin, IL-8 (+++ all doses)
Portal vein: LPS (+++ all doses)
Small intestine: expression of tight junction proteins claudin-1 (+ all doses) and occludin (+++ 1, ++ 2, 0 4) | Not studied |
| | Tang et al. [56] | Cynara scolymus L. (artichoke) in freeze-dried powder (Huimei Agricultural Science and Technology Co., Ltd., China)
Pretreatment, 1 hour before alcohol
0.4, 0.8 or 1.6 g/kg b.w., p.o., daily for 10 days
Male Institute of Cancer Research, mice, 7-week-old about 25 g | Ethanol 12 mL/kg b.w., p.o., daily for 10 days
Liver index: ↑
Serum: ALT, AST, TG, TC ↑
Liver: SOD, GSH ↓, MDA↑, expression level of TLR4 and NF-κB p50 ↑, score of steatosis, inflammation and necrosis ↑ | Liver index: (++ all doses)
Serum: ALT (0 0.4, + 0.8, +++ 1.6),TG (0 0.4, ++ 0.8 and 1.6), AST (+ 0.4 and 0.8, ++ 1.6), TC (+ 0.4, ++ 0.8 and 1.6)
Liver: SOD, GSH (++ 0.4 and 0.8, +++ 1.6), MDA (+ 0.4, +++ 0.8, and 1.6), score of steatosis (+ 0.4, ++ 0.8, and 1.6), score of inflammation (+ 0.4, ++ 0.8, and 1.6), score of necrosis (++ all doses), expression of TLR4 (+ 0.4, ++ 0.8, +++ 1.6), expression of NF-κB p50 (++ 0.4, +++ 0.8 and 1.6) | Not studied |
| | Dogan and Anuk [44] | Platanus orientalis L. leas water extract
20 or 60 mg/mL leaf infusion ad libitum, for 28 days
Male Wistar rats, 2 months aged, about 200 g | 20% ethanol water ad libitum for 28 days
Serum: AST, ALT, LDH, GGT, UA, urea ↑, cholesterol, HDL-c ↓
Liver: GSH ↓, GST, MDA ↑
Erythrocytes: GST, MDA ↑
Kidney: MDA ↑, SOD, GPx, CAT ↓ | Serum: GGT (- 20, ++ 60), ALT, urea (+ 20, 0 60), HDL-c (+ both doses), LDH (++ 20, +++ 60), cholesterol (++ 20, + 60), AST, UA (+++ both doses)
Liver: GSH and GST (+ both doses), MDA (++ both doses)
Erythrocytes: GST (0 both doses), MDA (++ 20, +++ 60)
Kidney: SOD (- 20, + 60), CAT (- 20, ++ 60), MDA (+++ both doses), GPx (+++ 20, ↑ 60) | Not studied |
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