| | Reference | Plant preparation, dose, treatment way and time, and animals | The name of drug, dose, exposure way and time, and negative effects | Protective effects of plant preparation | Effects of plant per se |
| | Kim et al. [100] | Dendropanax morbifera
The CHCl3 fraction of 70% methanol leaf extract
25 mg/kg once at 24 h before cisplatin and once a day for 5 days after, i.p.
Sprague Dawley male rats, 8 weeks, about 200 g | Cisplatin, a single administration of 6 mg/kg, i.p.
Body weight: ↓
Kidney/body weight ratio: ↑
Serum: BUN, CR ↑
Kidney: SOD ↓, cleaved caspase-3 and acute tubular necrosis score ↑ | Body weight: (++)
Kidney/body weight ratio: (+++)
Serum: CR (++), BUN (+++)
Kidney: acute tubular necrosis score (++), SOD and cleaved caspase-3 (+++) | Not studied |
| | Kpemissi et al. [102] | Combretum micranthum leaf ethanol-water (8 : 2) extract
200 or 400 mg/kg/day p.o., for 10 days
Male Wistar rats, 6-8-week-aged, 200-250 g | Cisplatin 7.5 mg/kg, i.p., a single injection on the 5th day
Body weight: ↓
Relative kidney weight: ↑
Serum: CR, urea, UA, ALT, AST, GGT, ALP ↑, TP, ALB, Ca, Mg, P, NO, FRAP ↓
Urine: CR, urea, UA, P ↓,
TP, ALB, Ca, Mg, ↑
Kidney: MDA ↑, FRAP, NO, GSH ↓ | Body weight (++ both doses)
Relative kidney weight: (+++ 200, ++ 400)
Serum: urea (+++ 200, ++ 400), CR, UA TP, ALB, Ca, Mg, P, ALT, AST, ALP, NO, FRAP (+++ both doses), GGT (↓ both doses)
Urine: CR, urea, UA TP, (+++ 200, ++ 400), ALB, Ca, Mg, P (+++ both doses)
Kidney: NO, GSH (++ both doses), FRAP (+++ 200, ++ 400), MDA (+++ both doses) | Not studied |
| | Hosseinian et al. [16] | Nigella sativa seeds 70% ethanol extract
100 or 200 mg/kg, i.p.
(i) Pretreatment (6 days)+saline for 5 days after cisplatin
(ii) Pretreatment (6 days)+extract for 5 days after cisplatin
Male Wistar rats, 230-300 g | Cisplatin 6 mg/kg on the 6th day of the experiment, i.p.
Serum: total SH ↓, MDA ↑
Kidney: total SH ↓, MDA ↑ slightly
Renal tissue damage: ↑ | (i) Serum: MDA (+++ both doses), total SH (+++100, ↑ 200)
Kidney: MDA (- both doses), total SH (+++ both)
Renal tissue damage: (++ both doses)
(ii) Serum: MDA (+++ both doses), total SH (↑ both)
Kidney: MDA (- 100, +++ 200), total SH (+++ both)
Renal tissue damage: (++ both doses) | Not studied |
| | Chen et al. [25] | Total flavonoids from Clinopodium chinense (Benth.)
Pretreatment
20, 40, or 80 mg/kg, i.g., for 15 days
Male Sprague-Dawley rats, 220-250 g | Doxorubicin-induced cardiotoxicity
3 mg/kg, i.p., every two days for a total of three injections
Body and heart weight: ↓
Serum: AST, LDH, CK ↑
Heart: SOD, CAT, GPx ↓, MDA ↑ | Body and heart weight: (++ 20, +++ 40 and 80)
Serum: CK, LDH (++ 20, +++ 40 and 80), AST (+++ all doses)
Heart: GPx (+ 20, ++ 40 and 80), CAT (++ all doses), MDA, SOD (++ 20, +++ 40 and 80) | 80 mg/kg only studied: none |
| | Ahmed et al. [24] | Allium sativum (garlic) aqueous extract
1 mL/100 g b.w., p.o., daily for 7 days before and 7 days after methotrexate
Male Wistar rats, 100–120 g | Methotrexate-induced nephrotoxicity
20 mg/kg, a single injection, i.p.
Serum: urea, CR, K, P ↑, Na ↓
Kidney: GSH, CAT ↓, MDA, ADA, NO ↑ | Serum: urea (↓), P (+), CR, K, Na (+++)
Kidney: MDA, NO (++), GSH, CAT, ADA (+++) | None |
| | Tag et al. [37] | Morus nigra (mulberry) leaves
50% ethanol extract
500 mg/kg, i.g., daily for 14 days
Male albino rats, 180–200 g | Methotrexate-induced hepatotoxicity, a single dose,
20 mg/kg, on 4th day, i.p.
Liver weight/body weight: ↑
Serum: AST, ALT, ALP, LDH ↑
Liver: total pathological score ↑, mean score of hepatocyte degeneration, congestion, cellular infiltration, fibrosis ↑ | Liver weight/body weight: (++)
Serum: ALP (++), AST, ALT, LDH ↓
Liver: total pathological score (++), mean score of hepatocyte degeneration, congestion, cellular infiltration and fibrosis (++) | Serum: AST, ALT, ALP, LDH ↓ |
| | Moghadam et al. [103] | Curcuma longa L., ethanol extract
100 or 200 mg/kg, p.o., for 30 days
Male Wistar rats, 220–280 g | Methotrexate-induced hepatotoxicity, a single dose 20 mg/kg i.p., on day 30th
Body weight:
Liver weight: ↑
Serum: ALB, TP ↓, ALT, AST, ALP, bilirubin ↑
Plasma: TAS ↓
Liver: SOD, GPx, CAT ↓, MDA, number of neutrophils, degree of injury ↑ | Body weight:
Liver weight ratio: (++ both doses)
Serum: AST, ALP (++ both doses), ALB, ALT, bilirubin, TP (++ 100, +++ 200)
Plasma: TAS (++100, +++200)
Liver: MDA, number of neutrophils (+ 100, ++ 200), degree of injury (++ both doses),
SOD, CAT, GPx (++ 100, +++ 200) | The higher dose:
Liver: CAT ↑
Plasma: TAS ↑ |
| | Omole et al. [26] | Kolaviron—a mixture of flavonoids obtained from Garcinia kola seeds
Pretreatment
200 or 400 mg/kg/d, p.o., for 14 days
Male Wistar rats, 120-150 g | Cyclophosphamide 50 mg/kg/d, i.p., 24 hours after the last dose of kolaviron, for 3 days
Relative heart weight: ↑
Heart: SOD, CAT, GPx, GSH ↓, LDH, CK, MDA, H2O2, MPO and cTn I ↑ | Relative heart weight: (+++ 200, ++ 400)
Heart: LDH, CK, cTn I, MPO, and GSH (++ both doses), GPx, CAT, MDA, H2O2 (+++ 200, ++ 400),
SOD (+++) both doses | None |
| | Sheweita et al. [101] | Essential oils of Foeniculum vulgare Miller (fennel) seeds, Cuminum cyminum L. (cumin) seeds, and Syzygium aromaticum L. (clove) flower buds (0.12 mL/kg b.w., 0.10 mL/kg b.w., and 0.106 mL/kg b.w., (1/50 LD50 doses), respectively), p.o. for 28 days
Male Swiss albino mice, about 25 g | Cyclophosphamide
2.5 mg/kg b.w. for 28 days, p.o.
Serum: ALT, AST, ALP ↑
Liver (S9 fraction): TBARS ↑; GSH, GPx, GR, GST, SOD, CAT ↓
Hepatic microsomal fraction: NADPH-cytochrome c reductase ↑ | Serum: ALT, AST, ALP (++ all oils)
Liver (S9 fraction): TBARS (++ clove oil, +++ fennel and cumin oils); GPx, GSH, GR, SOD, CAT (+++ all oils); GST ↑ all oils
Hepatic microsomal fraction: NADPH-cytochrome c reductase (0 all oils) | Liver: TBARS ↓,
GPx, CAT, GST ↑ (all oils), GR ↑ (cumin and clove), GSH, SOD ↑ (cumin), NADPH-cytochrome c reductase ↑ (all) |
| | Rahate and Rajasekaran [27] | Desmostachya bipinnata Stapf (L.) roots—the polyphenolic fraction of 70% methanol extract
100 or 200 mg/kg b.w., p.o., 21 days
Sprague-Dawley female rats, 150–200 g | Tamoxifen citrate
45 mg/kg b.w., p.o., 10th–21st days
Serum: protein ↓, AST, ALT, ALP, cholesterol, TG, urea, CR, UA, bilirubin ↑
Liver: LPO↑, GSH, GPx, SOD, CAT ↓ | Serum: protein, AST, ALT, cholesterol, TG, urea, UA (++ both doses), CR, bilirubin (++ 100, +++ 200),
ALP (++ 100, ↓ 200)
Liver: CAT (+ 100, ++ 200), LPO, GSH, GPx, SOD, (++ both doses) | Not studied |
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