| | Reference | Plant preparation, dose, treatment way and time, animals | The name of drug, dose, exposure way and time, negative effects | Protective effects of plant preparation | Effects of plant per se |
| | Ben Saad et al. [104] | Opuntia ficus-indica cladode extract obtained by homogenization with 10 mM Tris HCl, pH 7.4, and subsequent centrifugation
Pretreatment, 100 mg/kg b.w.
30-day pretreatment and then for 30 days together with lithium
Male Wistar rats, 2 months | Li (lithium carbonate), 25 mg/kg b.w., i.p., twice daily for 30 days
Serum: glucose, TC, TG, ALT, AST, LDH, ALP ↑
Blood: RBC, HGB, HCT ↓, WBC ↑
Liver: SOD, CAT, GPx ↓, MDA ↑ | Serum: ALT, AST (++), glucose, TC, TG, ALP, LDH (+++)
Blood: RBC, HGB, HCT, WBC (++)
Liver: CAT (++), SOD, GPx, MDA (+++) | None |
| | Khalil et al. [105] | Withania somnifera leaf
70% ethanol extract
Pretreatment, 100 mg/kg b.w., for 4 weeks
Male Wistar rats, 140–160 g | Isoproterenol 85 mg/kg b.w., s.c. on 29th and 30th days
Serum: TC, TG, VLDL-c, cTnI, CK-MB, LDH, AST, ALT ↑, HDL-c ↓
Heart: SOD, GR, GPx, GST ↓, MDA, weight ↑ | Serum: CK-MB (0), TC, TG, VLDL-c, cTnI, LDH (++), HDL-c, AST, ALT (+++)
Heart: SOD, weight (++), GR, GPx, GST, MDA (+++) | Serum: HDL-c ↑
Heart: GPx, GST ↑ |
| | Dianita et al. [106] | Labisia pumila var. alata water and 80% ethanolic extracts
100, 200, or 400 mg/kg, p.o., for 28 days
Male Wistar rats, 150-200 g | Isoproterenol, 85 mg/kg of s.c., on 29th and 30th day of the experiment
Serum: cTnI, CK-MB, LDH, AST, ALT ↑, SOD, CAT, GPx ↓
Heart: SOD, CAT, GPx ↓ | Serum: cTnI (water extract ++ all doses, ethanol extract ++ 100 and 200, +++ 400), CK-MB, LDH, AST, ALT, SOD, CAT, GPx (++ both extracts all doses)
Heart: SOD, GPx (water extract + 100, ++200 and 400, ethanol extract ++ all doses), CAT (++ both extracts, all doses) | Not studied |
| | Shahat et al. [107] | Rhus tripartita 80% methanol extract of the stem part of male genotype
250 or 500 mg/kg/day p.o., for 21 days (19-day-pretreatment)
Male Wistar rats, about 180 g | Isoproterenol 85 mg/kg, s.c. on 20th and 21st days
Serum: AST, ALT, GGT, ALP, LDH, CK, TC, TG, LDL-c, VLDL-c↑, HDL-c ↓
Heart: MDA ↑, NP-SH and TP ↓ | Serum: LDH, HDL-c (+ 250, ++500), AST, ALT, GGT, ALP, CK, TC, TG, LDL-c and VLDL-c (++ both doses)
Heart: MDA, NP-SH and TP (++ both doses) | Not studied |
| | Kemka Nguimatio et al. [108] | Aframomum melegueta seed water and methanol extracts
20 or 100 mg/kg for 28 days
Male Wistar rats, sexually experienced, 3-month-old, 200-250 g | Propylthiouracil-induced hypothyroidism causing ejaculatory complications
10 mg/[kg·day] for 28 days
Plasma: T ↓, TSH and prolactin ↑
Proejaculatory activity (contractile activity of the striated bulbospongiosus muscles): number of contractions after tactile stimulation and pharmacological activation (dopamine) ↓, intraseminal pressure after tactile stimulation and pharmacological activation (dopamine) ↓ | Water extract:
Plasma: TSH (0 both doses), T (+ 20, +++ 100), prolactin (+ 20, ++ 100)
Proejaculatory activity: contractions number after both stimuli (+++ 20, ↑ 100), intraseminal pressure: tactile stimulation (↑ both doses), pharmacological activation (+++ both doses)
Methanol extract:
Plasma: TSH (0 20, +100), T (+ 20, ++ 100), prolactin (++ 20, +100)
Proejaculatory activity: contractions number after both stimuli (↑ both doses), intraseminal pressure: tactile stimulation (↑ both doses), pharmacological activation (+++ 20, ↑100) | Not studied |
| | Nasri et al. [109] | Green tea 70% ethanol extract
Posttreatment: after iodixanol, 10 mg/kg/d, i.p., for 3 days
Pretreatment 10 mg/kg/d, i.p., for 3 days and iodixanol on the 3rd day
Male Wistar rats, 6-week-aged, 200-250 g | Iodixanol, a contrast medium
10 mL/kg, i.v., a single dose
Renal tubular cells: dilatation, degeneration, vacuolization, debris ↑ | Posttreatment:
Renal tubular cells: dilatation, degeneration, vacuolization, debris (++)
Pretreatment:
Renal tubular cells: dilatation, degeneration, vacuolization, debris (++)
Pretreatment showed a slightly better effect | Not studied |
| | El-Rahman et al. [110] | Saussurea lappa roots
70% ethanol extract
600 mg/kg, p.o., daily
Cotreatment for 2 weeks concurrently with the drug
Pretreatment for 1 week and then for 2 weeks concurrently with the drug
Male albino rats,150–160 g | Triamcinolone acetonide
40 mg/kg, i.p., twice a week for 2 weeks
Serum: TNF-α, CRP, IL-12, IgG, IgM ↓
Lung: GPx, SOD ↓, MDA ↑
Spleen: GPx, SOD ↓, MDA ↑
Histopathological lesion score: spleen and lung ↑ | Cotreatment:
Serum: TNF-α and CRP (0), IL-12 and IgG (+), IgM (++)
Lung: GPx (+), SOD, MDA (++)
Spleen: GPx, SOD, MDA (++)
Histopathological lesion: spleen and lung (++)
Pretreatment:
Serum: TNF-α, IL-12, CRP (0), IgG, IgM (++)
Lung: GPx, SOD, MDA (++)
Spleen: GPx, SOD (++), MDA (+++)
Histopathological lesion: spleen and lung (++) | Serum: TNF-α, CRP, IL-12, ↓, IgG, IgM ↑
Lung: GPx, SOD ↑, MDA ↓
Spleen: GPx, SOD ↑, MDA ↓ |
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