High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats

Figure 4

Inhibition of TLR4 by TAK-242 attenuated pancreatic injury and oxidative stress of HFD rats with AP. (a) TAK-242 or vehicle was injected intraperitoneally 30 minutes before AP modeling in HFD rats, and the animals were killed for analysis 12 h after the STC infusion. (b) In the HAP group, serious edema (blue arrow), massive acinar necrosis, inflammatory cell infiltration (black arrowhead), and intrapancreatic hemorrhage (yellow arrow) in the pancreas were observed. TAK-242 improved the histopathological damage. (c) Pathological score of pancreatic tissues in rats. (d) Percentage of necrotic cells was determined in the pancreas. (e) Pancreatic levels of MDA. (f) Pancreatic levels of LPO. (g) Pancreatic activities of SOD. (h) Pancreatic levels of GSH. versus HV group, ^# versus HAP group. Scale .

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