Changes in the Nrf2/Keap1 Ratio and PON1 Concentration in Plasma of Patients Undergoing the Left Main Coronary Artery Stenting

Figure 6

(a) Spearman correlation between PON1 and Nrf2 during the perioperative LMPCI procedure. The negative correlation is suggested to be related to Keap1 involvement in Nrf2 degradation after the procedure. (b) Spearman correlation between PON1 and Keap1 during the perioperative LMPCI procedure. The positive correlation between the Keap1 and PON1 reflects the switch-off time for Nrf2 when its concentration after mobilization of the antioxidant response is silenced. Nrf2 withdrawing by Keap1 leaves the activated PON1 in the circulation. Hence, the day after surgery, we observe a positive correlation between PON1 and Keap1. (c) Spearman correlation between PON1 and Nrf2/Keap1 during the perioperative LMPCI procedure.

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