Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

Figure 6

TLR4 antagonist mimics the effects of acupuncture on inflammation inhibition, and TLR4 agonist reverses these effects of acupuncture. The levels of IL-6 (a, b) and TNF-α (e, f) in the hippocampus and plasma were detected in sham, 2VO, 2VO+Acu, 2VO+TAK-242, and 2VO+DMSO groups by ELISA (). The levels of IL-6 (c, d) and TNF-α (g, h) in the hippocampus and plasma were detected in sham, 2VO, 2VO+Acu, 2VO+Acu+Saline, 2VO+Acu+LPS, 2VO+LPS groups by ELISA (). , , and , compared as indicated. NS: no significance.

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