Differential Gender-Dependent Patterns of Cardiac Fibrosis and Fibroblast Phenotypes in Aging Mice

Figure 6

Schematic representation of gender-dependent cardiac fibrosis and CF populations with age. Eccentric cardiac hypertrophy is present in the aged male whereas concentric cardiac hypertrophy is present in the female. Replacement myocardial fibrosis was evidenced in the aged male heart over reactive myocardial one in the female. Collagen I is predominant in the aged male hearts whereas collagen III is the main component in the female’s. CFs in the aged male heart were mainly recruited from resident PDGFRα⁺ populations. CF: cardiac fibroblast.